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Polycefin, a New Prototype of a Multifunctional Nanoconjugate Based on Poly(β-l-malic acid) for Drug Delivery

A new prototype of nanoconjugate, Polycefin, was synthesized for targeted delivery of antisense oligonucleotides and monoclonal antibodies to brain tumors. The macromolecular carrier contains: 1. biodegradable, nonimmunogenic, nontoxic β-poly(l-malic acid) of microbial origin; 2. Morpholino antisens...

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Autors principals: Lee, Bong-Seop, Fujita, Manabu, Khazenzon, Natalya M., Wawrowsky, Kolja A., Wachsmann-Hogiu, Sebastian, Farkas, Daniel L., Black, Keith L., Ljubimova, Julia Y., Holler, Eggehard
Format: Artigo
Idioma:Inglês
Publicat: 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487710/
https://ncbi.nlm.nih.gov/pubmed/16536461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc0502457
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