Overexpression of the DMP1 C-Terminal Fragment Stimulates FGF23 and Exacerbates the Hypophosphatemic Rickets Phenotype in Hyp Mice

Dentin matrix protein-1 (DMP1) or phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) inactivation results in elevation of the phosphaturic hormone fibroblast growth factor (FGF)-23, leading to hypophosphatemia, aberrant vitamin D metabolism, and rickets/osteomalac...

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Detalhes bibliográficos
Main Authors: Martin, A., David, V., Li, H., Dai, B., Feng, J. Q., Quarles, L. D.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487625/
https://ncbi.nlm.nih.gov/pubmed/22930691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1062
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