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Randomized phase II study of two schedules of flavopiridol given as timed sequential therapy with cytosine arabinoside and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia

BACKGROUND: Flavopiridol is a protein-bound, cytotoxic, cyclin dependent kinase inhibitor. A phase II trial of flavopiridol followed by ara-C and mitoxantrone with flavopiridol given by 1-h bolus for adults with newly-diagnosed, poor-risk acute myelogenous leukemia yielded 67% complete remission wit...

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書誌詳細
主要な著者: Karp, Judith E., Garrett-Mayer, Elizabeth, Estey, Elihu H., Rudek, Michelle A., Smith, B. Douglas, Greer, Jacqueline M., Drye, D. Michelle, Mackey, Karen, Dorcy, Kathleen Shannon, Gore, Steven D., Levis, Mark J., McDevitt, Michael A., Carraway, Hetty E., Pratz, Keith W., Gladstone, Douglas E., Showel, Margaret M., Othus, Megan, Doyle, L. Austin, Wright, John J., Pagel, John M.
フォーマット: Artigo
言語:Inglês
出版事項: Ferrata Storti Foundation 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487449/
https://ncbi.nlm.nih.gov/pubmed/22733022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.062539
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