Novel Therapy for Atherosclerosis Using Recombinant Immunotoxin Against Folate Receptor β–Expressing Macrophages

BACKGROUND: Folate receptor β (FRβ) is induced during macrophage activation. A recombinant immunotoxin consisting of the truncated Pseudomonas exotoxin A (PE38) conjugated to an anti-FRβ antibody (anti–FRβ-PE38) has been reported to kill activated macrophages in inflammatory diseases. To elucidate t...

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Bibliographische Detailangaben
Hauptverfasser: Furusho, Yuko, Miyata, Masaaki, Matsuyama, Takami, Nagai, Taku, Li, Hua, Akasaki, Yuichi, Hamada, Narisato, Miyauchi, Takahiro, Ikeda, Yoshiyuki, Shirasawa, Takahiro, Ide, Kanako, Tei, Chuwa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2012
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487340/
https://ncbi.nlm.nih.gov/pubmed/23130174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.112.003079
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