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Impact of Stoichiometry Representation on Simulation of Genotype-Phenotype Relationships in Metabolic Networks
Genome-scale metabolic networks provide a comprehensive structural framework for modeling genotype-phenotype relationships through flux simulations. The solution space for the metabolic flux state of the cell is typically very large and optimization-based approaches are often necessary for predictin...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3486866/ https://ncbi.nlm.nih.gov/pubmed/23133362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002758 |
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