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New methodology for the preparation of 3-hydroxy-2-pyridinone (3,2-HOPO) chelators - Reaction of amines with a novel electrophilic 3,2-HOPO precursor

The preparation of the new electrophilic iminium ester mesylate salt 5 and its reaction with primary and secondary amines have been investigated. Aniline, t-butylamine, and secondary amines react with 5 via ring opening to give the corresponding HOPO derivatives in high yields. The usefulness of thi...

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Detaylı Bibliyografya
Asıl Yazarlar: Lambert, Timothy N., Chittamuru, Sumathi, Jacobs, Hollie K., Gopalan, Aravamudan S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2002
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486744/
https://ncbi.nlm.nih.gov/pubmed/23125467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0040-4039(02)01730-6
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