Genotypic and Phenotypic Evaluation of the Evolution of High-Level Daptomycin Nonsusceptibility in Vancomycin-Resistant Enterococcus faecium

Whole-genome sequencing and cell membrane studies of three clonal Enterococcus faecium strains with daptomycin MICs of 4, 32, and 192 μg/ml were performed, revealing nonsynonymous single nucleotide variants in eight open reading frames, including those predicted to encode a phosphoenolpyruvate-depen...

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Hlavní autoři: Humphries, Romney M., Kelesidis, Theodoros, Tewhey, Ryan, Rose, Warren E., Schork, Nicholas, Nizet, Victor, Sakoulas, George
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486580/
https://ncbi.nlm.nih.gov/pubmed/22948885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01318-12
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