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Enhanced Recognition and Neutralization of HIV-1 by Antibody-Derived CCR5-Mimetic Peptide Variants

A tyrosine-sulfated CCR5-mimetic peptide, CCR5mim1, inhibits HIV-1 infection more efficiently than sulfopeptides based on the CCR5 amino terminus. Here we characterized sulfopeptide chimeras of CCR5mim1 and the heavy-chain CDR3 of the antibody PG16. Two chimeras bound a range of envelope glycoprotei...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Chiang, Jessica J., Gardner, Matthew R., Quinlan, Brian D., Dorfman, Tatyana, Choe, Hyeryun, Farzan, Michael
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486504/
https://ncbi.nlm.nih.gov/pubmed/22933279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00967-12
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