Temporal Association of HLA-B*81:01- and HLA-B*39:10-Mediated HIV-1 p24 Sequence Evolution with Disease Progression

HLA-B*81:01 and HLA-B*39:10 alleles have been associated with viremic control in HIV-1 subtype C infection. Both alleles restrict the TL9 epitope in p24 Gag, and cytotoxic-T-lymphocyte (CTL)-mediated escape mutations in this epitope have been associated with an in vitro fitness cost to the virus. We...

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Detalhes bibliográficos
Main Authors: Ntale, R. S., Chopera, D. R., Ngandu, N. K., Assis de Rosa, D., Zembe, L., Gamieldien, H., Mlotshwa, M., Werner, L., Woodman, Z., Mlisana, K., Abdool Karim, S., Gray, C. M., Williamson, C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486481/
https://ncbi.nlm.nih.gov/pubmed/22933291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00539-12
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