Modification of One Epitope-Flanking Amino Acid Allows for the Induction of Friend Retrovirus-Specific CD8(+) T Cells by Adenovirus-Based Immunization

While Friend retrovirus-infected mice readily mount a vigorous CD8(+) T cell response to the leader-gag-derived peptide GagL(85–93), no GagL(85–93)-specific T cells were detectable in mice immunized against Friend virus (FV) with viral vectors or DNA vaccines. By exchanging one epitope-flanking amin...

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Hlavní autoři: Gödel, Philipp, Windmann, Sonja, Dietze, Kirsten K., Dittmer, Ulf, Bayer, Wibke
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486454/
https://ncbi.nlm.nih.gov/pubmed/22933287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01607-12
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