Kaposi's Sarcoma-Associated Herpesvirus MicroRNAs Target IRAK1 and MYD88, Two Components of the Toll-Like Receptor/Interleukin-1R Signaling Cascade, To Reduce Inflammatory-Cytokine Expression

Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is the causative agent of KS, an important AIDS-associated malignancy. KSHV expresses at least 18 different mature microRNAs (miRNAs). We identified interleukin-1 receptor (IL-1R)-associated kinase 1 (IRAK1) as a potential target of miR-K12-9...

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Detalles Bibliográficos
Main Authors: Abend, Johanna R., Ramalingam, Dhivya, Kieffer-Kwon, Philippe, Uldrick, Thomas S., Yarchoan, Robert, Ziegelbauer, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486292/
https://ncbi.nlm.nih.gov/pubmed/22896623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01147-12
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