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DNA gyrase action involves the introduction of transient double-strand breaks into DNA.

DNA gyrase from Escherichia coli, in the presence of ATP, can both separate catenated DNA circles and unknot knotted DNA. Both these reactions require passage of a DNA segment through a transient double-strand break in DNA. Evidence that transient double-strand breaks are also involved in the superc...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Mizuuchi, K, Fisher, L M, O'Dea, M H, Gellert, M
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1980
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348605/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6246508/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.4.1847
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