Serum IgM Antibodies Contribute to High Levels of Opsonophagocytic Activities in Toddlers Immunized with a Single Dose of the 9-Valent Pneumococcal Conjugate Vaccine

In immunogenicity trials of pneumococcal conjugate vaccines (PCVs), only IgG antibody concentrations to pneumococcal capsular polysaccharides (PPSs) are usually determined, along with the opsonophagocytic activity (OPA) of antipneumococcal antibodies. We aimed to determine the role of both IgG and I...

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Detalhes bibliográficos
Main Authors: Simell, Birgit, Nurkka, Anu, Ekström, Nina, Givon-Lavi, Noga, Käyhty, Helena, Dagan, Ron
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485875/
https://ncbi.nlm.nih.gov/pubmed/22875604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00248-12
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