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Enzymatic Glycosylation of Nonbenzoquinone Geldanamycin Analogs via Bacillus UDP-Glycosyltransferase

Geldanamycin (GM) is a naturally occurring anticancer agent isolated from several strains of Streptomyces hygroscopicus. However, its potential clinical utility is compromised by its severe toxicity and poor water solubility. For this reason, considerable efforts are under way to make new derivative...

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Main Authors: Wu, Cheng-Zhu, Jang, Jae-Hyuk, Woo, Mihee, Ahn, Jong Seog, Kim, Joong Su, Hong, Young-Soo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485733/
https://ncbi.nlm.nih.gov/pubmed/22923401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02004-12
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