Phase I trial of split-dose induction docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy followed by curative surgery combined with postoperative radiotherapy in patients with locally advanced oral and oropharyngeal squamous cell cancer (TISOC-1)

BACKGROUND: Induction chemotherapy (ICT) with docetaxel, cisplatin and fluorouracil (TPF) followed by radiotherapy is an effective treatment option for unresectable locally advanced head and neck cancer. This phase I study was designed to investigate the safety and tolerability of a split-dose TPF I...

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Detalhes bibliográficos
Main Authors: Oertel, Katrin, Spiegel, Karin, Schmalenberg, Harald, Dietz, Andreas, Maschmeyer, Georg, Kuhnt, Thomas, Sudhoff, Holger, Wendt, Thomas G, Guntinas-Lichius, Orlando
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485626/
https://ncbi.nlm.nih.gov/pubmed/23083061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-483
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