Phosphodiesterase 11A (PDE11A) Gene Defects in Patients with ACTH-Independent Macronodular Adrenal Hyperplasia (AIMAH): Functional Variants May Contribute to Genetic Susceptibility of Bilateral Adrenal Tumors

CONTEXT: Phosphodiesterases (PDEs) are key regulatory enzymes of intracellular cAMP levels. PDE11A function has been linked to predisposition to adrenocortical tumors. OBJECTIVE: The aim of the study was to study the PDE11A gene in a large cohort of patients with ACTH-independent macronodular adrena...

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Hauptverfasser: Vezzosi, Delphine, Libé, Rossella, Baudry, Camille, Rizk-Rabin, Marthe, Horvath, Anelia, Levy, Isaac, René-Corail, Fernande, Ragazzon, Bruno, Stratakis, Constantine A., Vandecasteele, Grégoire, Bertherat, Jérôme
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2012
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Hot Topics in Translational Endocrinology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485605/
https://ncbi.nlm.nih.gov/pubmed/22996146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-2275
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