Population pharmacokinetics of farletuzumab, a humanized monoclonal antibody against folate receptor alpha, in epithelial ovarian cancer

PURPOSE: The purpose of this analysis was to develop a population pharmacokinetic model for farletuzumab, a humanized immunoglobulin (Ig)G(1) monoclonal antibody (mAb) to the folate receptor alpha, which is a receptor over-expressed in ovarian cancer, but largely absent from normal tissue. METHODS:...

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Autores principales: Farrell, Colm, Schweizer, Charles, Wustner, Jason, Weil, Susan, Namiki, Masayuki, Nakano, Tomohisa, Nakai, Kenya, Phillips, Martin D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer-Verlag 2012
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485533/
https://ncbi.nlm.nih.gov/pubmed/22955257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-012-1959-y
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