Everolimus and Sirolimus in Combination with Cyclosporine Have Different Effects on Renal Metabolism in the Rat

Enhancement of calcineurin inhibitor nephrotoxicity by sirolimus (SRL) is limiting the clinical use of this drug combination. We compared the dose-dependent effects of the structurally related everolimus (EVL) and sirolimus (SRL) alone, and in combination with cyclosporine (CsA), on the rat kidney....

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Bibliografiske detaljer
Main Authors: Bohra, Rahul, Schöning, Wenzel, Klawitter, Jelena, Brunner, Nina, Schmitz, Volker, Shokati, Touraj, Lawrence, Ryan, Arbelaez, Maria Fernanda, Schniedewind, Björn, Christians, Uwe, Klawitter, Jost
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485290/
https://ncbi.nlm.nih.gov/pubmed/23118926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048063
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