Everolimus and Sirolimus in Combination with Cyclosporine Have Different Effects on Renal Metabolism in the Rat

Enhancement of calcineurin inhibitor nephrotoxicity by sirolimus (SRL) is limiting the clinical use of this drug combination. We compared the dose-dependent effects of the structurally related everolimus (EVL) and sirolimus (SRL) alone, and in combination with cyclosporine (CsA), on the rat kidney....

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Main Authors: Bohra, Rahul, Schöning, Wenzel, Klawitter, Jelena, Brunner, Nina, Schmitz, Volker, Shokati, Touraj, Lawrence, Ryan, Arbelaez, Maria Fernanda, Schniedewind, Björn, Christians, Uwe, Klawitter, Jost
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485290/
https://ncbi.nlm.nih.gov/pubmed/23118926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048063
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