Sildenafil Enhances Neurogenesis and Oligodendrogenesis in Ischemic Brain of Middle-Aged Mouse

Adult neural stem cells give rise to neurons, oligodendrocytes and astrocytes. Aging reduces neural stem cells. Using an inducible nestin-CreER(T2)/R26R-yellow fluorescent protein (YFP) mouse, we investigated the effect of Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, on nestin lineage ne...

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Autori principali: Zhang, Rui Lan, Chopp, Michael, Roberts, Cynthia, Wei, Min, Wang, Xinli, Liu, Xianshuang, Lu, Mei, Zhang, Zheng Gang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485244/
https://ncbi.nlm.nih.gov/pubmed/23118941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048141
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