HLA and Celiac Disease Susceptibility: New Genetic Factors Bring Open Questions about the HLA Influence and Gene-Dosage Effects

Celiac disease (CD) is a chronic inflammatory disorder triggered after gluten ingestion in genetically susceptible individuals. The major genetic determinants are HLA-DQA1*05 and HLA-DQB1*02, which encode the DQ2 heterodimer. These alleles are commonly inherited in cis with DRB1*03∶01, which is asso...

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Detalhes bibliográficos
Main Authors: Medrano, Luz María, Dema, Bárbara, López-Larios, Arturo, Maluenda, Carlos, Bodas, Andrés, López-Palacios, Natalia, Figueredo, M. Ángeles, Fernández-Arquero, Miguel, Núñez, Concepción
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485232/
https://ncbi.nlm.nih.gov/pubmed/23119005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048403
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