Ppm1-Encoded Polyprenyl Monophosphomannose Synthase Activity Is Essential for Lipoglycan Synthesis and Survival in Mycobacteria

The biosynthesis of mycobacterial mannose-containing lipoglycans, such as lipomannan (LM) and the immunomodulator lipoarabinomanan (LAM), is carried out by the GT-C superfamily of glycosyltransferases that require polyprenylphosphate-based mannose (PPM) as a sugar donor. The essentiality of lipoglyc...

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Bibliografiske detaljer
Main Authors: Rana, Amrita K., Singh, Albel, Gurcha, Sudagar S., Cox, Liam R., Bhatt, Apoorva, Besra, Gurdyal S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485146/
https://ncbi.nlm.nih.gov/pubmed/23118955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048211
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