Combinations of Griffithsin with Other Carbohydrate-Binding Agents Demonstrate Superior Activity Against HIV Type 1, HIV Type 2, and Selected Carbohydrate-Binding Agent-Resistant HIV Type 1 Strains

Carbohydrate-binding agents (CBAs) are potential HIV microbicidal agents with a high genetic barrier to resistance. We wanted to evaluate whether two mannose-specific CBAs, recognizing multiple and often distinct glycan structures on the HIV envelope gp120, can interact synergistically against HIV-1...

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Detalhes bibliográficos
Main Authors: Férir, Geoffrey, Huskens, Dana, Palmer, Kenneth E., Boudreaux, Daniel M., Swanson, Michael D., Markovitz, David M., Balzarini, Jan, Schols, Dominique
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Preclinical Studies/Drug Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484736/
https://ncbi.nlm.nih.gov/pubmed/22607556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2012.0026
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