Calcium dependence of phalloidin-induced liver cell death.

The role of Ca2+ in toxic liver cell death was studied with primary cultures of adult rat hepatocytes. Within 1 hr of exposure to phalloidin, a bicyclic heptapeptide isolated from the mushroom Amanita pahlloides, at 50 micrograms/ml, 60--70% of the cells were dead (trypan blue stainable). There was...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Kane, A B, Young, E E, Schanne, F A, Farber, J L
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1980
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348448/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6767245/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.2.1177
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