Large Oncosomes in Human Prostate Cancer Tissues and in the Circulation of Mice with Metastatic Disease

Oncosomes are tumor-derived microvesicles that transmit signaling complexes between cell and tissue compartments. Herein, we show that amoeboid tumor cells export large (1- to 10-μm diameter) vesicles, derived from bulky cellular protrusions, that contain metalloproteinases, RNA, caveolin-1, and the...

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Bibliografiske detaljer
Main Authors: Di Vizio, Dolores, Morello, Matteo, Dudley, Andrew C., Schow, Peter W., Adam, Rosalyn M., Morley, Samantha, Mulholland, David, Rotinen, Mirja, Hager, Martin H., Insabato, Luigi, Moses, Marsha A., Demichelis, Francesca, Lisanti, Michael P., Wu, Hong, Klagsbrun, Michael, Bhowmick, Neil A., Rubin, Mark A., D'Souza-Schorey, Crislyn, Freeman, Michael R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2012
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483805/
https://ncbi.nlm.nih.gov/pubmed/23022210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.07.030
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