Large Oncosomes in Human Prostate Cancer Tissues and in the Circulation of Mice with Metastatic Disease

Oncosomes are tumor-derived microvesicles that transmit signaling complexes between cell and tissue compartments. Herein, we show that amoeboid tumor cells export large (1- to 10-μm diameter) vesicles, derived from bulky cellular protrusions, that contain metalloproteinases, RNA, caveolin-1, and the...

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Opis bibliograficzny
Główni autorzy: Di Vizio, Dolores, Morello, Matteo, Dudley, Andrew C., Schow, Peter W., Adam, Rosalyn M., Morley, Samantha, Mulholland, David, Rotinen, Mirja, Hager, Martin H., Insabato, Luigi, Moses, Marsha A., Demichelis, Francesca, Lisanti, Michael P., Wu, Hong, Klagsbrun, Michael, Bhowmick, Neil A., Rubin, Mark A., D'Souza-Schorey, Crislyn, Freeman, Michael R.
Format: Artigo
Język:Inglês
Wydane: American Society for Investigative Pathology 2012
Hasła przedmiotowe:
Regular Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483805/
https://ncbi.nlm.nih.gov/pubmed/23022210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.07.030
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