Quantitative Proteomic Analysis of Niemann-Pick Disease, Type C1 Cerebellum Identifies Protein Biomarkers and Provides Pathological Insight

Niemann-Pick disease, type C1 (NPC1) is a fatal, neurodegenerative disorder for which there is no definitive therapy. In NPC1, a pathological cascade including neuroinflammation, oxidative stress and neuronal apoptosis likely contribute to the clinical phenotype. While the genetic cause of NPC1 is k...

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Detalhes bibliográficos
Main Authors: Cologna, Stephanie M., Jiang, Xiao-Sheng, Backlund, Peter S., Cluzeau, Celine V. M., Dail, Michelle K., Yanjanin, Nicole M., Siebel, Stephan, Toth, Cynthia L., Jun, Hyun-sik, Wassif, Christopher A., Yergey, Alfred L., Porter, Forbes D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483225/
https://ncbi.nlm.nih.gov/pubmed/23144710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047845
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