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Calcitriol Modulates the CD46 Pathway in T Cells

The complement regulator CD46 is a costimulatory molecule for human T cells that induces a regulatory Tr1 phenotype, characterized by large amounts of IL-10 secretion. Secretion of IL-10 upon CD46 costimulation is largely impaired in T cells from patients with multiple sclerosis (MS). Vitamin D can...

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Detalhes bibliográficos
Main Authors: Kickler, Karoline, Ni Choileain, Siobhan, Williams, Anna, Richards, Anna, Astier, Anne L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483209/
https://ncbi.nlm.nih.gov/pubmed/23144765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048486
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