A tissue-specific chromatin loop activates the erythroid ankyrin-1 promoter

The human ankyrin-1 gene (ANK1) contains 3 tissue-specific alternative promoters. We have shown previously that the erythroid-specific ankyrin 1 (ANK1E) core promoter contains a 5′ DNase I hypersensitive site (HS) with barrier insulator function that prevents gene silencing in vitro and in vivo. Mut...

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Detalhes bibliográficos
Main Authors: Yocum, Ashley O., Steiner, Laurie A., Seidel, Nancy E., Cline, Amanda P., Rout, Emily D., Lin, Jolinta Y., Wong, Clara, Garrett, Lisa J., Gallagher, Patrick G., Bodine, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482866/
https://ncbi.nlm.nih.gov/pubmed/22968456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-450262
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