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Solid-state characterization of lacidipine/PVP K(29/32) solid dispersion primed by solvent co-evaporation

BACKGROUND: Lacidipine (LCDP) is a 1,4-dihydropyridine derivative categorized as an anti-hypertensive Ca2+ channel blocker having very low solubility, and thus very low oral bioavailability, which presents a challenge to the formulation scientists. Homogeneous distribution of poorly water-soluble dr...

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Detalhes bibliográficos
Main Authors: Mukharya, Amit, Chaudhary, Shivang, Mansuri, Niyaz, Misra, Arun K
Formato: Artigo
Idioma:Inglês
Publicado em: Medknow Publications & Media Pvt Ltd 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482771/
https://ncbi.nlm.nih.gov/pubmed/23119238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/2230-973X.100048
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