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Sprouty1 Haploinsufficiency Prevents Renal Agenesis in a Model of Fraser Syndrome
Deficiency of the extracellular matrix molecule FRAS1, normally expressed by the ureteric bud, leads to bilateral renal agenesis in humans with Fraser syndrome and blebbed (Fras1(bl/bl)) mice. The metanephric mesenchyme of these mutants fails to express sufficient Gdnf, which activates receptor tyro...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Nephrology
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3482732/ https://ncbi.nlm.nih.gov/pubmed/23064016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012020146 |
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