Docosahexaenoic acid-induced unfolded protein response, cell cycle arrest, and apoptosis in vascular smooth muscle cells are triggered by Ca(2+)-dependent induction of oxidative stress

Proliferation of vascular smooth muscle cells is a characteristic of pathological vascular remodeling and represents a significant therapeutic challenge in several cardiovascular diseases. Docosahexaenoic acid (DHA), a member of the n-3 polyunsaturated fatty acids, was shown to inhibit proliferation...

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Detalhes bibliográficos
Main Authors: Crnkovic, Slaven, Riederer, Monika, Lechleitner, Margarete, Hallström, Seth, Malli, Roland, Graier, Wolfgang F., Lindenmann, Jörg, Popper, Helmut, Olschewski, Horst, Olschewski, Andrea, Frank, Saša
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2012
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Original Contribution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482662/
https://ncbi.nlm.nih.gov/pubmed/22391221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.02.036
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