Bcl-x Pre-mRNA Splicing Regulates Brain Injury after Neonatal Hypoxia-Ischemia

The bcl-x gene appears to play a critical role in regulating apoptosis in the developing and mature CNS and following CNS injury. Two isoforms of Bcl-x are produced as a result of alternative pre-mRNA splicing: Bcl-x(L) (the long form) is anti-apoptotic, while Bcl-x(S) (short form) is pro-apoptotic....

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Main Authors: Xiao, Qingli, Ford, Andria L., Xu, Jan, Yan, Ping, Lee, Kuang-Yung, Gonzales, Ernesto, West, Tim, Holtzman, David M., Lee, Jin-Moo
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2012
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482490/
https://ncbi.nlm.nih.gov/pubmed/23015448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2617-12.2012
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