Histone deacetylases inhibitor Trichostatin A ameliorates DNFB-induced allergic contact dermatitis and reduces epidermal Langerhans cells in mice

BACKGROUND: Histone deacetylases (HDACs) influence chromatin organization, representing a key epigenetic regulatory mechanism in cells. Trichostatin A (TSA), a potent HDAC inhibitor, has anti-tumor and anti-inflammatory effects. Allergic contact dermatitis (ACD) is a T-cell-mediated inflammatory rea...

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Bibliografiske detaljer
Main Authors: Shi, Yu-Ling, Gu, Jun, Park, Jun-Yang, Xu, Ying-Ping, Yu, Fu-Shin, Zhou, Li, Mi, Qing-Sheng
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482471/
https://ncbi.nlm.nih.gov/pubmed/22999682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jdermsci.2012.09.001
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