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Mechanistic correlations between two itch biomarkers, IL-31 cytokine and beta-endorphin neuropeptide, via STAT3/calcium axis in atopic dermatitis
BACKGROUND: Itch is the cardinal symptom of atopic dermatitis (AD). Beta-endorphin, a neuropeptide, is increased in both AD skin and sera. IL-31, an itch-relevant cytokine, activates IL-31 receptors in keratinocytes. However, how IL-31 and beta-endorphin interact in AD skin remains elusive. OBJECTIV...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3482403/ https://ncbi.nlm.nih.gov/pubmed/22578170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2133.2012.11047.x |
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