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Acute and Chronic Cardioprotection by the Enkephalin Analogue, Eribis Peptide 94, is Mediated via Activation of Nitric Oxide Synthase and Adenosine Triphosphate-Regulated Potassium Channels

BACKGROUND/AIMS: Eribis peptide 94 (EP 94) is a new enkephalin derivative which potently binds to the μ- and δ-opioid receptor. In this study, we determined the effects of EP 94 and potential mechanism(s) involved in cardioprotection of the rat heart. METHODS AND RESULTS: An acute (5 and 10 min into...

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Autors principals: Gross, Garrett J., Hsu, Anna, Nithipatikom, Kasem, Pfeiffer, Adam W., Bobrova, Irina, Bissessar, Erik
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482344/
https://ncbi.nlm.nih.gov/pubmed/22814415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000340058
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