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APPL1 regulates basal NF-κB activity by stabilizing NIK
APPL1 is a multifunctional adaptor protein that binds membrane receptors, signaling proteins and nuclear factors, thereby acting in endosomal trafficking and in different signaling pathways. Here, we uncover a novel role of APPL1 as a positive regulator of transcriptional activity of NF-κB under bas...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Company of Biologists
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3482318/ https://ncbi.nlm.nih.gov/pubmed/22685329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.105171 |
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