NGF Inhibits Human Leukemia Proliferation by Downregulating Cyclin A1 Expression through Promoting Acinus/CtBP2 Association

Cyclin A1 is essential for leukemia progression, and its expression is tightly regulated by acinus, a nuclear speckle protein. However, the molecular mechanism of how acinus mediates cyclin A1 expression remains elusive. Here we show that transcription corepressor CtBP2 directly binds acinus, which...

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Bibliografiske detaljer
Main Authors: Chan, Chi Bun, Liu, Xia, Jang, Sung-Wuk, Hsu, Stephen I-Hong, Williams, Ifor, Kang, Sumin, Chen, Jing, Ye, Keqiang
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481846/
https://ncbi.nlm.nih.gov/pubmed/19668232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.236
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