Mycobacterium tuberculosis Prokaryotic Ubiquitin-like Protein-deconjugating Enzyme Is an Unusual Aspartate Amidase

Deamidase of Pup (Dop), the prokaryotic ubiquitin-like protein (Pup)-deconjugating enzyme, is critical for the full virulence of Mycobacterium tuberculosis and is unique to bacteria, providing an ideal target for the development of selective chemotherapies. We used a combination of genetics and chem...

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Autori principali: Burns, Kristin E., McAllister, Fiona E., Schwerdtfeger, Carsten, Mintseris, Julian, Cerda-Maira, Francisca, Noens, Elke E., Wilmanns, Matthias, Hubbard, Stevan R., Melandri, Francesco, Ovaa, Huib, Gygi, Steven P., Darwin, K. Heran
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Protein Synthesis and Degradation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481346/
https://ncbi.nlm.nih.gov/pubmed/22942282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.384784
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