Identification and Quantification of a New Family of Peptide Endocannabinoids (Pepcans) Showing Negative Allosteric Modulation at CB(1) Receptors

The α-hemoglobin-derived dodecapeptide RVD-hemopressin (RVDPVNFKLLSH) has been proposed to be an endogenous agonist for the cannabinoid receptor type 1 (CB(1)). To study this peptide, we have raised mAbs against its C-terminal part. Using an immunoaffinity mass spectrometry approach, a whole family...

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Detalhes bibliográficos
Main Authors: Bauer, Mark, Chicca, Andrea, Tamborrini, Marco, Eisen, David, Lerner, Raissa, Lutz, Beat, Poetz, Oliver, Pluschke, Gerd, Gertsch, Jürg
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481297/
https://ncbi.nlm.nih.gov/pubmed/22952224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.382481
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