AhR activation underlies the CYP1A autoinduction by A-998679 in rats

Xenobiotic-mediated induction of cytochrome P450 (CYP) drug metabolizing enzymes (DMEs) is frequently encountered in drug discovery and can influence disposition, pharmacokinetic, and toxicity profiles. The CYP1A subfamily of DMEs plays a central role in the biotransformation of several drugs and en...

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Detalhes bibliográficos
Main Authors: Liguori, Michael J., Lee, Chih-Hung, Liu, Hong, Ciurlionis, Rita, Ditewig, Amy C., Doktor, Stella, Andracki, Mark E., Gagne, Gerard D., Waring, Jeffrey F., Marsh, Kennan C., Gopalakrishnan, Murali, Blomme, Eric A. G., Yang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2012
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481155/
https://ncbi.nlm.nih.gov/pubmed/23112805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2012.00213
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