Prevalence of KRAS, BRAF, and PIK3CA somatic mutations in patients with colorectal carcinoma may vary in the same population: clues from Sardinia

BACKGROUND: Role of KRAS, BRAF and PIK3CA mutations in pathogenesis of colorectal cancer (CRC) has been recently investigated worldwide. In this population-based study, we evaluated the incidence rates and distribution of such somatic mutations in genetically isolated population from Sardinia. METHO...

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Główni autorzy: Palomba, Grazia, Colombino, Maria, Contu, Antonio, Massidda, Bruno, Baldino, Giovanni, Pazzola, Antonio, Ionta, MariaTeresa, Capelli, Francesca, Trova, Vittorio, Sedda, Tito, Sanna, Giovanni, Tanda, Francesco, Budroni, Mario, Palmieri, Giuseppe, Cossu, Antonio
Format: Artigo
Język:Inglês
Wydane: BioMed Central 2012
Hasła przedmiotowe:
Research
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480926/
https://ncbi.nlm.nih.gov/pubmed/22931052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-178
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