Lactic Acid Is Elevated in Idiopathic Pulmonary Fibrosis and Induces Myofibroblast Differentiation via pH-Dependent Activation of Transforming Growth Factor-β

Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex disease for which the pathogenesis is poorly understood. In this study, we identified lactic acid as a metabolite that is elevated in the lung tissue of patients with IPF. Objectives: This study examines the effect of lactic acid on myofibr...

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Detalhes bibliográficos
Main Authors: Kottmann, Robert Matthew, Kulkarni, Ajit A., Smolnycki, Katie A., Lyda, Elizabeth, Dahanayake, Thinesh, Salibi, Rami, Honnons, Sylvie, Jones, Carolyn, Isern, Nancy G., Hu, Jian Z., Nathan, Steven D., Grant, Geraldine, Phipps, Richard P., Sime, Patricia J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480515/
https://ncbi.nlm.nih.gov/pubmed/22923663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201201-0084OC
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