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Recombination Activating Gene-2 Regulates CpG-Mediated Interferon-α Production in Mouse Bone Marrow-Derived Plasmacytoid Dendritic Cells
Using mice that lack recombination activating gene-2 (Rag2), we have found that bone marrow-derived plasmacytoid dendritic cells (pDCs) as main producers of interferon-α (IFNα) require Rag2 for normal development. This is a novel function for Rag2, whose classical role is to initiate B and T cell de...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3480463/ https://ncbi.nlm.nih.gov/pubmed/23110142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047952 |
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