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Novel Method for Probing the Specificity Binding Profile of Ligands: Applications to HIV Protease
A detailed understanding of factors influencing the binding specificity of a ligand to a set of desirable targets and undesirable decoys is a key step in the design of potent and selective therapeutics. We have developed a general method for optimizing binding specificity in ligand–receptor complexe...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3480184/ https://ncbi.nlm.nih.gov/pubmed/18384529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2008.00659.x |
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