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Farnesyl pyrophosphate is an endogenous antagonist to ADP-stimulated P2Y(12) receptor-mediated platelet aggregation
Farnesyl pyrophosphate (FPP) is an intermediate in cholesterol biosynthesis, and it has also been reported to activate platelet LPA (lysophosphatidic acid) receptors. The aim of this study was to investigate the role of extracellular FPP in platelet aggregation. Human platelets were studied with lig...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3479660/ https://ncbi.nlm.nih.gov/pubmed/22628078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH11-10-0749 |
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