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Detection of a rare BCR–ABL tyrosine kinase fusion protein in H929 multiple myeloma cells using immunoprecipitation (IP)-tandem mass spectrometry (MS/MS)

Hypothesis directed proteomics offers higher throughput over global analyses. We show that immunoprecipitation (IP)–tandem mass spectrometry (LC-MS/MS) in H929 multiple myeloma (MM) cancer cells led to the discovery of a rare and unexpected BCR–ABL fusion, informing a therapeutic intervention using...

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Autors principals: Breitkopf, Susanne B., Yuan, Min, Pihan, German A., Asara, John M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479604/
https://ncbi.nlm.nih.gov/pubmed/22988110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212759109
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