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Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity

Continual and rapid mutation of seasonal influenza viruses by antigenic drift necessitates the almost annual reformulation of flu vaccines, which may offer little protection if the match to the dominant circulating strain is poor. S139/1 is a cross-reactive antibody that neutralizes multiple HA stra...

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Main Authors: Lee, Peter S., Yoshida, Reiko, Ekiert, Damian C., Sakai, Naoki, Suzuki, Yasuhiko, Takada, Ayato, Wilson, Ian A.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479480/
https://ncbi.nlm.nih.gov/pubmed/23027945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212371109
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