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Intrinsic flexibility of snRNA hairpin loops facilitates protein binding
Stem–loop II of U1 snRNA and Stem–loop IV of U2 snRNA typically have 10 or 11 nucleotides in their loops. The fluorescent nucleobase 2-aminopurine was used as a substitute for the adenines in each loop to probe the local and global structures and dynamics of these unusually long loops. Using steady-...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3479389/ https://ncbi.nlm.nih.gov/pubmed/23012481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.035006.112 |
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