Insulin Receptor and IRS-1 Co-immunoprecipitation with SOCS-3, and IKKα/β Phosphorylation are Increased in Obese Zucker Rat Skeletal Muscle

AIMS: We evaluated if select pro-inflammatory cytokines and/or the protein suppressor of cytokine signaling 3 (SOCS-3) could account for decreased insulin-stimulated phosphatidylinositol 3-kinase (PI3-K) activity in the skeletal muscle of the obese Zucker rat. MAIN METHODS: Eight lean and eight obes...

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Hlavní autoři: ZOLOTNIK, ILYA A., FIGUEROA, TANIA Y., YASPELKIS, BEN B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478879/
https://ncbi.nlm.nih.gov/pubmed/22982470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2012.08.038
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