A Selective Neurokinin-1 Receptor Antagonist in Chronic PTSD: a Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Trial

The substance P-neurokinin-1 receptor (SP-NK(1)R) system has been extensively studied in experimental models of stress, fear, and reward. Elevated cerebrospinal fluid (CSF) SP levels were reported previously in combat-related PTSD. No medication specifically targeting this system has been tested in...

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Main Authors: Mathew, Sanjay J., Vythilingam, Meena, Murrough, James W., Zarate, Carlos A., Feder, Adriana, Luckenbaugh, David A., Kinkead, Becky, Parides, Michael K., Trist, David G., Bani, Massimo S., Bettica, Paolo U., Ratti, Emiliangelo M., Charney, Dennis S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478767/
https://ncbi.nlm.nih.gov/pubmed/21194898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.euroneuro.2010.11.012
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