Hypoxia-inducible factor-1 alpha–dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

Recent studies have demonstrated dramatic shifts in metabolic supply-and-demand ratios during inflammation, a process resulting in localized tissue hypoxia within inflammatory lesions (“inflammatory hypoxia”). As part of the adaptive immune response, T cells are recruited to sites of inflammatory hy...

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Autores principales: Clambey, Eric T., McNamee, Eóin N., Westrich, Joseph A., Glover, Louise E., Campbell, Eric L., Jedlicka, Paul, de Zoeten, Edwin F., Cambier, John C., Stenmark, Kurt R., Colgan, Sean P., Eltzschig, Holger K.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478644/
https://ncbi.nlm.nih.gov/pubmed/22988108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202366109
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